全文获取类型
收费全文 | 5249篇 |
免费 | 268篇 |
国内免费 | 18篇 |
学科分类
医药卫生 | 5535篇 |
出版年
2023年 | 26篇 |
2022年 | 29篇 |
2021年 | 183篇 |
2020年 | 100篇 |
2019年 | 164篇 |
2018年 | 217篇 |
2017年 | 124篇 |
2016年 | 127篇 |
2015年 | 130篇 |
2014年 | 224篇 |
2013年 | 279篇 |
2012年 | 455篇 |
2011年 | 455篇 |
2010年 | 273篇 |
2009年 | 227篇 |
2008年 | 347篇 |
2007年 | 337篇 |
2006年 | 336篇 |
2005年 | 319篇 |
2004年 | 290篇 |
2003年 | 249篇 |
2002年 | 232篇 |
2001年 | 54篇 |
2000年 | 48篇 |
1999年 | 54篇 |
1998年 | 42篇 |
1997年 | 37篇 |
1996年 | 19篇 |
1995年 | 33篇 |
1994年 | 19篇 |
1993年 | 8篇 |
1992年 | 10篇 |
1991年 | 14篇 |
1990年 | 11篇 |
1989年 | 8篇 |
1988年 | 10篇 |
1987年 | 6篇 |
1986年 | 6篇 |
1985年 | 6篇 |
1984年 | 2篇 |
1982年 | 2篇 |
1981年 | 4篇 |
1979年 | 4篇 |
1974年 | 2篇 |
1964年 | 1篇 |
1962年 | 2篇 |
1961年 | 1篇 |
1960年 | 3篇 |
1933年 | 1篇 |
1929年 | 1篇 |
排序方式: 共有5535条查询结果,搜索用时 218 毫秒
101.
102.
Gutschmidt Kristina Musumeci Olimpia Díaz-Manera Jordi Chien Yin-Hsiu Knop Karl Christian Wenninger Stephan Montagnese Federica Pugliese Alessia Tavilla Graziana Alonso-Pérez Jorge Hwu Paul Wuh-Liang Toscano Antonio Schoser Benedikt 《Journal of neurology》2021,268(7):2482-2492
Journal of Neurology - Pompe disease is one of the few neuromuscular diseases with an approved drug therapy, which has been available since 2006. Our study aimed to determine the real-world... 相似文献
103.
Zdzisław Świderski Jordi Miquel Isabel Montoliu Carlos Feliu David I. Gibson 《Parasitology research》2013,112(9):3325-3333
Intrauterine embryonic development in the microphallid trematode Maritrema feliui is examined by means of transmission electron microscopy. Both fertilization and eggshell formation take place in the ootype. The eggshell is formed from a shell globule material derived from the vitelline cells combined with secretions of Mehlis' gland. The proximal uterus is packed with unembryonated eggs of the oligolecithal type, each composed of a fertilized oocyte and several vitelline cells, all surrounded by the shell. Intrauterine embryonic development of the egg is followed to the early stage of outer embryonic envelope formation, resulting in an embryo of ~20 blastomeres of three different types: macromeres, mesomeres and micromeres. The first equal cleavage division of the zygote produces two macromeres. The outer envelope is of cellular origin and formed by the cytoplasmic fusion of two macromeres, which become situated at opposite poles in the peripheral layer of the embryo just beneath the eggshell. Simultaneously, other blastomeres multiply and differentiate, whereas several micromeres exhibit clear signs of degeneration or apoptosis. These results show that the embryonic development of M. feliui starts in utero and represents an example of early stage ovoviviparity. A reduction in the number of blastomeres results from a continued degeneration of micromeres, which after autolysis and re-absorption, appear to represent an important source of nutritive reserves for the embryo. The embryonic development of this digenean is discussed in relation to its life cycle. 相似文献
104.
105.
Turjeman Adi Babich Tanya Pujol Miquel Carratalà Jordi Shaw Evelyn Gomila-Grange Aina Vuong Cuong Addy Ibironke Wiegand Irith Grier Sally MacGowan Alasdair Vank Christiane Cuperus Nienke van den Heuvel Leo Leibovici Leonard Eliakim-Raz Noa 《European journal of clinical microbiology & infectious diseases》2021,40(9):2005-2010
European Journal of Clinical Microbiology & Infectious Diseases - Complicated urinary tract infection (cUTI) is a frequent cause of morbidity. In this multinational retrospective cohort study,... 相似文献
106.
Jesús Rodríguez-Baño Jerónimo Pachón Jordi Carratalà Pablo Ryan Inmaculada Jarrín María Yllescas José Ramón Arribas Juan Berenguer 《Clinical microbiology and infection》2021,27(2):244-252
ObjectivesThe objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters.MethodsA cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs).ResultsIn all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22–0.47; p < 0.001) for tocilizumab, 0.82 (0.71–1.30; p 0.82) for IHDC, 0.61 (0.43–0.86; p 0.006) for PDC, and 1.17 (0.86–1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02–0.17; p < 0.001).ConclusionsTocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situation. 相似文献
107.
108.
109.
Zdzisław Świderski Isabel Montoliu Carlos Feliu David I. Gibson Jordi Miquel 《Acta parasitologica / Witold Stefański Institute of Parasitology, Warszawa, Poland》2013,58(4):478-485
The tegument of the microphallid digenean Maritrema feliui, examined by means of TEM, is described as a syncytial epithelium organised into two layers. The outer layer is an external anucleate, cytoplasmic region connected to a second region composed of nucleate perikarya (cytons) deeply embedded in the surrounding cortical parenchyma. The surface layer of the tegument is covered by a plasma membrane with many deep invaginations, which are apparently pinocytotic. This layer also bears numerous large, electron-dense spines of two types, which are intracellular and attached to the basal plasma membrane. Its cytoplasm is rich in free ribosomes, contains numerous mitochondria, disc-shaped granules frequently arranged in a rouleau, and several large, moderately electron-dense, membranous bodies. The subtegumentary perikarya and their nuclei, which are both flattened, are described in detail, as are their connections with the surface tegument. These perikarya appear to be the source of the disc-shaped granules and some of the other inclusions present in the surface layer. The main characteristics of the tegumental structure of M. feliui are commented upon in relation to the findings of previous publications and their suggested functions. 相似文献
110.